https://ir.vidyasagar.ac.in/jspui/handle/123456789/7182 Tue, 17 Feb 2026 07:24:39 GMT 2026-02-17T07:24:39Z https://ir.vidyasagar.ac.in/jspui/handle/123456789/7190 Title: Vitamin C and E Supplementation Can Mitigate NaF Mediated Hematological and Hepatic Disorders in Adult Wistar Rats Authors: Adhikary, Subhamay; Pal, Priyankar; Biswas, Sagnik; Maity, Jeet; Kumar Mukhopadhyay, Prabir Abstract: The study aimed to investigate the effect of combined vitamin E and C, on hematological and hepatic systems of adult male Wistar rats with fluoride toxicity. Eighteen rats were randomly divided into three groups such as control, treated (given NaF, 20 mg/kg bw/rat/day), and supplemented (NaF and vitamin E-200 mg/kg bw + C- 400 mg/kg bw). Altered hematological parameters like erythrocyte count, leukocyte count and hemoglobin concentration were seen in NaF groups. Estimation of osmotic fragility of erythrocyte showed a marked increase fragile erythrocytes in fluoride-treated groups compared to control and supplemented groups. Total thiol concentration was also decreased due fluoride fluoride-induced oxidative stress and it was protected in supplementary groups. The oxidative imbalance induced by NaF in liver was evaluated by estimating the activity of antioxidant enzyme superoxide dismutase and catalase and with estimation of lipid peroxidation and protein oxidation product malondialdehyde and protein carbonyl. All enzymatic and non-enzymatic markers of oxidative imbalance were significantly altered (increased/decreased) due to fluoride toxicity, which was again observed to be protected in the supplemented group. The histopathological analysis of the liver also proved the mitigatory effect of the combined vitamin E+C on fluorideinduced hepatic insult. Description: PP:1-29 Tue, 01 Jun 2021 00:00:00 GMT https://ir.vidyasagar.ac.in/jspui/handle/123456789/7190 2021-06-01T00:00:00Z https://ir.vidyasagar.ac.in/jspui/handle/123456789/7189 Title: Anti-Diabetic and Anti-Oxidative Effect of Aloe Vera (L.) Gel: An In- Vitro Approach Authors: Pal, Dibya; Singha Roy, Sajani; Das, Shibani; Ghosh, Debidas Abstract: Medicinal plants are utilized in various formulations to treat a wide range of illnesses, includig diabetes.The present study focused on anti-diabetic and anti-oxidative effect of Aloe vera (L.) in an in-vitro model. Wistar strain albino rats with less than 350 mg/dl of fasting blood glucose level on the 7th day of Streptozotocin (STZ) injection were considered for this study and left for obverting a chronic state of diabetes. On the 29th day of STZ injection, rats were sacrificed and targeted tissues were incubated for 2 hours in an in-vitro medium with 1, 2, and 4 mg of Aloe vera (L.) hydro-ethanol (40:60) extract (AVHE) separately and subjected to evaluation with adopted parameters. Results showed a significant (p˂0.05) recovery in the glucose-6- phosphatase and oxidative stress markers along with GOT and GPT activities in extract-charged groups whereas no significant (p>0.05) changes was noted in hexokinase enzymes activity compared to the unexposed diabetic group. Statistical analysis showed no significant (p>0.05) difference in the recovery level among 1, 2, and 4 mg doses of AVHE. It can be concluded that AVHE has direct ameliorative effect on diabetes and its linked oxidative stress markers. Description: PP:30-38 Tue, 01 Jun 2021 00:00:00 GMT https://ir.vidyasagar.ac.in/jspui/handle/123456789/7189 2021-06-01T00:00:00Z https://ir.vidyasagar.ac.in/jspui/handle/123456789/7188 Title: Management of Bisphenol-A Induced Hepato-Renal Disorder in Wistar Rat by Wheatgrass Aqueous Extract Co-Administration Authors: Barman, Ananya; Ghosh, Angshita; Kumar Kar, Tarun; Chattopadhyay, Sandip Abstract: Bisphenol-A (or BPA) is a renowned endocrine disruptor in current use. This study concentrated on the restorative effects of wheatgrass methanolic extract (WG-ME) on the liver and kidney in rats treated with BPA. For this purpose, 18 Wistar rats were divided into 3 groups: Control; BPA (100mg/kg); BPA+ WG-ME (100 mg/kg BPA + 200mg/kg WG-ME) by oral gavage for 28 days study period. Dissected liver and kidney were procured and stored at -20oC for the evaluation of cellular antioxidant status. For the analysis of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine levels, which have a role in measuring liver and kidney toxicity, blood samples were collected. In parallel, BPA decreases cellular antioxidant levels super-di-oxide (SOD), catalase and GPx in liver and kidney. The hepato-renal functional tests and antioxidant enzyme levels were significantly improved with the addition of WG-ME oral consumption. These findings provided that protective effect of WG-ME improving BPA-induced metabolic alterations. Description: PP:39-47 Tue, 01 Jun 2021 00:00:00 GMT https://ir.vidyasagar.ac.in/jspui/handle/123456789/7188 2021-06-01T00:00:00Z https://ir.vidyasagar.ac.in/jspui/handle/123456789/7187 Title: In-Vitro Effect of Most Potent Ethyl-Acetate Solvent Fraction of Curcuma Amada Rhizomes for the Management of Diabetes Induced Male Reproductive Impairments Authors: Sarkar, Riya; Ghosh, Debidas Abstract: Curcuma amada is employed as a medicinal herb in traditional medicinal practices. The aim of this research was to determine if the rhizome of Curcuma amada could directly improve the male reproductive system of diabetic rats. To explore whether the ethylacetate fraction of Curcuma amada rhizomes has a direct antioxidative impact on STZinduced diabetic animals, the activities of antioxidant enzymes such as catalase and superoxide dismutase, as well as the level of Thiobarbituric acid reactive substances in testicular tissue, were evaluated. The activities of Δ5, 3β- hydroxysteroid dehydrogenase, and 17β- hydroxysteroid dehydrogenase were also evaluated to determine the direct impact of the ethyl-acetate fraction on the androgenic domain. When the testes of diabetic rats were directly exposed to the ethyl-acetate fraction of the plant, it did not lead to any significant recovery in the said enzyme activities. Following the direct exposure of the ethyl-acetate fraction of Curcuma amada rhizomes to the testes of type 1 diabetic rats, said parameters associated with oxidative stress, exhibited a positive improvement towards control. This improvement could be ascribed to the antioxidative phytomolecules present in the ethyl-acetate fraction of the plant, which effectively suppressed testicular oxidative stress by scavenging free radicals in the target tissue. Description: PP:48-59 Tue, 01 Jun 2021 00:00:00 GMT https://ir.vidyasagar.ac.in/jspui/handle/123456789/7187 2021-06-01T00:00:00Z