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Determination of LD50 and ED50 Value of Nicotine Doses in Relation to Body and Organs Weight Along with Haematological Parameter: A Day-Dependent Experimental Study on Male Albino Rats

2022-04-20T03:08:13Z

Title: Determination of LD50 and ED50 Value of Nicotine Doses in Relation to Body and Organs Weight Along with Haematological Parameter: A Day-Dependent Experimental Study on Male Albino Rats Authors: Paul, Monalisa; Kundu, Chitali; Yasmin, Merina; Kar, Dr. Suman; Sinha, Sandip Kumar Abstract: As we know that nicotine toxicity is accountable for several damages at cellular level. Cellular damage directly or indirectly causes unhealthy impact on body and organ weight. Still now a little research work has been conducted regarding the nicotine induced changes in body and organ weight (Heart, Liver etc)along with haematological (RBC, WBC, Platelets and hemoglobin) parameters in male albino rat. In this study we tried to find out the effects of LD50and ED50 of nicotine on above parameters. We appliedLD50 and ED50 doses of nicotine on day-dependent study (10, 15 and 20 days) and observed its effect on rat model. In this experimental study the doses of LD50 and ED50 of nicotine were 51mg/kg body weight and 3.5mg/kg body weight respectively. After 10 days of treatment, no significant changes were observed. But during 15 days of nicotine treatment, it produced toxic effects on the studied parameters. But all those parameters were more aggravated during 20 days of nicotine application. All the results were highly significant at P<0.05 level in compared to that of control group. In conclusion, it is suggested that the effective dose of nicotine of 3.5mg/kg body weight caused toxic effects in this day-dependent study. Description: PP:5-15

Anatomy and Histomorphological Characterization of Olfactory Neuroepithelium in an Indian Loach Lepidocephalichthys Guntea (Hamilton, 1822): A Comprehensive Interpretation

2022-04-20T03:07:49Z

Title: Anatomy and Histomorphological Characterization of Olfactory Neuroepithelium in an Indian Loach Lepidocephalichthys Guntea (Hamilton, 1822): A Comprehensive Interpretation Authors: Barman, Swasti; Sarkar, Swaraj K.; De, Subrata K. Abstract: Lepidocephalichthys guntea (Hamilton, 1822) is a common scavenger fish of South East Asia. This species is listed on IUCN Red List as ‘Least Concern’. The present study highlights detail olfactory structure of a common Indian scavenger loach, [Order: Cypriniformes, Family: Cobitidae] to explore the morphoanatomical peculiarities in special reference to their habitat concern. Description: PP:1-4

Assessment Anaemia and Hypertension in Relation to Different BMI Categories Among Paddy Threshing Workers

2022-04-13T08:12:10Z

Title: Assessment Anaemia and Hypertension in Relation to Different BMI Categories Among Paddy Threshing Workers Authors: Mahata, Hiranmoy; Dhara, Prakash C. Abstract: As Agriculture workers do the paddy threshing work by manual means as well as using a paddy machine with foot pedal. Threshing activity was very strenuous and physiologically demanding. The main aim of the present investigation was to evaluate the occurrence anaemia and blood pressure in relation to nutritional status of the paddy threshing workers. For the study 352 workers engaged in paddy threshing were selected at random from villages of different districts of West Bengal state. The Socioeconomic Status (SES) was evaluated by modified Kuppuswami Scale. The nutritional status of the workers was determined by cut-off values of Body Mass Index (BMI) as prescribed by WHO. The general health condition of paddy threshing workers was evaluated by the measurement of blood pressure and blood haemoglobin concentration level. The results revealed that most of the paddy threshing workers was belonging to upper lower socioeconomic class (male: 81.33%; female: 84.72 %). The chronic energy deficiency (CED) was prevalent (male: 26.11%; female: 40.71%) among the workers engaged in paddy threshing. In the study population, the prevalence of anaemia was 46.11% in males and 69.19% in females, which was more than the global value. The results indicated that the energy deficiency in paddy workers (BMI <18.5 kg/m2) of both sexes were more likely to be anemic compared to of normal and overweight individuals. The occurrence of hypertension was more in males compared to that of females. The incidence of hypotension in females was higher than that of males. It was concluded that the occurrence of anaemia and abnormalities of blood pressure among paddy threshing workers was linked to their BMI values. Description: PP:16-32

Ameliorating Efficacy of Riboflavin in Arsenic Induced Cytotoxicity in the Liver of Swiss Albino Mice

2022-04-13T08:08:34Z

Title: Ameliorating Efficacy of Riboflavin in Arsenic Induced Cytotoxicity in the Liver of Swiss Albino Mice Authors: Dey, Sajal Kumar Abstract: Arsenic has been found to cause severe cytological alterations in animal hepatic tissues. Oxidative stress induced by arsenic produces reactive oxygen intermediates. Present study aims to explore the extent of damage caused by sub lethal dose of arsenic, and to monitor the biochemical, cytological and histopathological changes caused by the toxic heavy metal. High levels of stress enzymes like phosphatase, peroxidase were noted in the liver. Down regulation of antioxidant enzymes like, peroxidase, dismutase, and catalase were noted in arsenic infected liver. Overall protein metabolism was affected due to arsenic induced cytotoxicity. Present study indicates abnormalities in all such cellular proteins and enzymes. The results also indicate the efficacy of riboflavin in combating arsenic induced cytotoxicity in liver to reduce oxidative stress caused by arsenic in the vitalorgans. Description: PP: 33-44